The perfect entry to retinol.

Cosmedix Define 45g

$135.00 $108.00
- +
or 4 payments of $27.00 with Learn more

Cosmedix Define is a unique blend of three Hydroxy Acids and Retinol to smooth out skin tone. With a cream base, Cosmedix Define is a gentle formula for dry skins, sensitive skins or those new to Retinol, for resurfacing and age-defying benefits. 

*Not suitable while pregnant or breastfeeding.


Problematic Skin, Reactive Skin, Sensitive Skin


  • Exfoliates epidemal cells to reveal a brighter complexion
  • Stimulates collagen and elastin production for skin renewal
  • Helps combat acne and breakouts
  • Improves the appearance of fine lines and imperfections


Water, Caprylic/Capric Triglyceride, Lactic Acid (L), Glyceryl Stearate, Glycerin, Cetearyl Alcohol, Sodium Hydroxide, Retinyl Acetate, Polysorbate 60, Albumen, Benzyl Alcohol, Cetyl Alcohol, Malic Acid (L), Olea Europaea (Olive) Fruit Oil, Tartaric Acid (L), Stearic Acid, Retinol, Pichia/Resveratrol Ferment Extract, Resveratrol Dimethyl Ether, Galactoarabinan, Hydroxyproline (L), Citrus Grandis (Grapefruit) Peel Oil, Cananga Odorata (Ylang Ylang) Flower Oil, Bisabolol (L-alpha), Tocopheryl Acetate (D-alpha), Glycine Soja (Soybean) Oil, Hamamelis Virginiana (Witch Hazel) Water, Aloe Barbadensis Leaf Juice Powder, Allantoin, Prunus Persica (Peach) Fruit Extract, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Helianthus Annuus (Sunflower) Seed Oil, Myristoyl Alcohol, Tocopherol, Alcohol, Lecithin, Myristic Acid, Palmitic Acid, BHT, Stearyl Alcohol, Limonene, Linalool, Benzyl Benzoate, Phenoxyethanol.


Free Shipping for all orders $55 or above (sent as Standard Post).

For orders under $55: • Standard Post $10. Received within 7 business days • Express Post $16.95 Received within 3 business days • Shipping times vary depending on location

Easy 30 Day Returns

View Shipping + Returns Policy

How To Use It

Apply a small amount to freshly cleansed skin 2-4 times weekly as part of your nightly regimen. Use as tolerated. Follow with moisturiser.

Clean, clinical, and luxurious – This is one of the first cosmeceutical ranges that we curated at the Clinic. This brand was founded by nurse practitioners who emphasized the importance of overall skin health through strict formulation. We have been recommending this brand for over 20 years. Our top Hero products are Benefit clean, purity clean , serum 16,opti eye crystal.


Active ingredients

Medically trained staff

Video consult & in store

100% Australian


Free shipping & Returns

Local orders over $50 & within 30 days

Customer Reviews
4.9 Based on 7 Reviews
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Filter Reviews:
Julie W.
Australia Australia
Cosmedix define - smooth

This is my second purchase of Cosmedix Define and have felt and can see a difference in my skin. I was using it twice a week and now using it 3 time a week. My skin is smoother and feels less dry and ‘tired’ if that make sense. I feel it works best after a scrub and to have fresh clean feeling skin

The Clinic

Thanks for sharing your review with us Julie. We are delighted to hear your skin has felt smoother and more hydrated.

Natalie H.
Australia Australia

Helps smooth out the appearance of your skin, minimises redness and assists with combating breakouts.

The Clinic

Hi Natalie, thanks so much for your review. We are happy to hear your positive results.

Jennifer A.
Great product

Love this product, really helps my skin, fast delivery too.